SPRAVATO – In 2019, the FDA grantedapproval for Spravato (Esketamine) totreat Treatment Resistant Depression (TRD). Initially approved as an anesthetic agent in 1970, ketamine was later discovered to have a rapid and potent antidepressant effect when administered intravenously. Notably, Spravato is an intranasal formulation, that is patient administered under supervision. It became the first and only form of ketamine approved for use in treating depression. To find out more visit: